What is the MixSep™ Process?

Developed at Sigris Research, the patented MixSep™ process is based on a rotating magnetic mixing field which suspends and mixes magnetic particles without agitating the test medium. The rotating magnetic field provides superior mixing efficiency without fluid shear and the high collision frequency between particles and target leads to a high rate of affinity capture.   

By using the MixSep™ process in our instruments, sample yield and purification is greatly improved over conventional techniques.  Also, the combination of mixing and separation function in a single compact mechanism significantly simplifies instrumentation development.

Although very simple, MixSep™ has a wide range of applications for purification needs in molecular and cell biology, and can provide fast, reproducible, and reliable results. Furthermore, MixSep™ can be easily scaled-up for the purification from large sample volumes.

A New Horizon In Biomagnetic Purification

In both molecular diagnostics and basic research, fast and reproducible isolation of nucleic acids, proteins and rare cells from large numbers of samples is becoming increasingly important. Current sample preparation techniques in molecular diagnostics are unable to meet the growing sample workload at a reasonable cost. Automated purification systems such as SieNA offer a cost effective way to address this need.

Magnetic Mixing Offers

• Substantial increase in sample yield and purity.
• Cost effective automation.
• High efficiency mixing without fluid shear.
• Fast binding kinetics from high collision frequency between particles and target species.
• Seamless integration of mixing and separation functions.
• Simultaneous processing of many samples.
• Simple to scale-up for large volumes (100ml and over).
• Applicable to nucleic acids (DNA, RNA), viruses, proteins and microorganisms and rare cells such as stem cells, dendritic cells.